On Friday evening, November 17, 1911, three Howard University undergraduate students, with the assistance of their faculty adviser, gave birth to the Omega Psi Phi Fraternity. This event occurred in the office of biology Professor Ernest E. Just, the faculty adviser, in the Science Hall (now known as Thirkield Hall). The three liberal arts students were Edgar A. Love, Oscar J. Cooper and Frank Coleman.

From the initials of the Greek phrase meaning "friendship is essential to the soul," the name Omega Psi Phi was derived. The phrase was selected as the motto. Manhood, scholarship, perseverance and uplift were adopted as cardinal principles. A decision was made regarding the design for the pin and emblem, and thus ended the first meeting of the Omega Psi Phi Fraternity.

The next meeting was conducted on November 23, 1911. Edgar Love became the first Grand Basileus (National President). Cooper and Coleman were selected Grand keeper of the Records (National Secretary) and Grand keeper of Seals (National Treasurer), respectively. Eleven Howard University undergraduate men were selected as charter members. Alpha Chapter was organized with fourteen charter members on December 15, 1911. Love, Cooper and Coleman were elected the chapter's first Basileus, Keeper of Records, and Keeper of Seals, respectively.